Novartis Vaccines and Diagnostics, one of the world’s leading pharmaceutical manufacturers, continues to turn to BE&K Building Group as it expands its 167-acre campus in Holly Springs, North Carolina – home to the first cell culture-derived influenza vaccines manufacturing complex in the United States.

BE&K Building Group provided construction management services for an expansion to the Holly Springs campus, a planned 460,000 sf complex. Referred to as the Advanced Development Manufacturing (ADM) Project, BE&K Building Group’s assignment consisted of three distinct components.

A new, 37,800 sf, two-story Technical Services Building (TSB) provides office space for around 120 people. Offices are located on the second floor with conference rooms and support areas. The first floor will consist of the Novartis and U.S. Government secure employee entrance, maintenance shop area, reception area, document control, and other support areas. Associated roadways, parking, lighting and utilities are a part of the project’s scope.

The Clinical Trial Manufacturing (CTM) component consists of retrofitting 8,900 sf of existing office space located within Novartis’ Viral Pilot Plant (VPP). New construction provides clean room production space for Novartis’ formulation, filling (vial and pre-filled syringe), lyophilization and hand-packaging operations. Architectural construction for the converted office space implements clean room wall and ceiling panels with integral doors, windows, air return walls, and corner coving. The clean room ceiling systems are designed to be walkable, providing critical maintenance access to equipment located throughout the interstitial space. Mechanical systems include the design and fabrication of a roof-mounted modular mechanical penthouse/air-handler assembly. This assembly will be fabricated off site in five modules and assembled on site. Two modules are airhandler units while the remaining three modules will serve as the mechanical penthouse. The mechanical penthouse sections will house mechanical piping, supply/return-air plenums, constant air volume boxes, and provide dry maintenance access to coils and other components. This modular approach eases the space utilized in the above-ceiling areas and facilitates installation of the high density of ductwork required for the clean room air distribution.

The Warehouse High Density Vertical Storage component

  • Owner:Novartis Vaccines and Diagnostics
  • Location:Holly Springs, North Carolina
  • Project Type:Construction Management